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中风后吞咽困难

Dysphagia following Stroke.

作者信息

Paciaroni Maurizio, Mazzotta Giovanni, Corea Francesco, Caso Valeria, Venti Michele, Milia Paolo, Silvestrelli Giorgio, Palmerini Francesco, Parnetti Lucilla, Gallai Virgilio

机构信息

Stroke Unit, Department of Neuroscience, University of Perugia, Perugia, Italy.

出版信息

Eur Neurol. 2004;51(3):162-7. doi: 10.1159/000077663. Epub 2004 Apr 1.

Abstract

BACKGROUND

Dysphagia is common after stroke. We aimed to study the prognosis of dysphagia (assessed clinically) over the first 3 months after acute stroke and to determine whether specific neurovascular-anatomical sites were associated with swallowing dysfunction.

METHODS

We prospectively examined consecutive patients with acute first-ever stroke. The assessment of dysphagia was made using standardized clinical methods. The arterial territories involved were determined on CT/MRI. All patients were followed up for 3 months.

RESULTS

34.7% of 406 patients had dysphagia. Dysphagia was more frequent in patients with hemorrhagic stroke (31/63 vs. 110/343; p = 0.01). In patients with ischemic stroke, the involvement of the arterial territory of the total middle cerebral artery was more frequently associated with dysphagia (28.2 vs. 2.2%; p < 0.0001). Multivariate analysis revealed that stroke mortality and disability were independently associated with dysphagia (p < 0.0001).

CONCLUSIONS

The frequency of dysphagia was relatively high. Regarding anatomical-clinical correlation, the most important factor was the size rather than the location of the lesion. Dysphagia assessed clinically was a significant variable predicting death and disability at 90 days.

摘要

背景

吞咽困难在中风后很常见。我们旨在研究急性中风后前3个月吞咽困难(临床评估)的预后,并确定特定的神经血管解剖部位是否与吞咽功能障碍相关。

方法

我们对连续的首次急性中风患者进行前瞻性研究。吞咽困难采用标准化临床方法进行评估。通过CT/MRI确定受累的动脉区域。所有患者随访3个月。

结果

406例患者中有34.7%存在吞咽困难。吞咽困难在出血性中风患者中更常见(31/63对110/343;p = 0.01)。在缺血性中风患者中,大脑中动脉主干动脉区域受累更常与吞咽困难相关(28.2%对2.2%;p < 0.0001)。多变量分析显示,中风死亡率和残疾与吞咽困难独立相关(p < 0.0001)。

结论

吞咽困难的发生率相对较高。关于解剖学与临床的相关性,最重要的因素是病变的大小而非位置。临床评估的吞咽困难是预测90天时死亡和残疾的重要变量。

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