Kato K, Tanaka T
Critical Care Center, Kansai Medical University Hospital.
Nihon Rinsho. 1992 May;50(5):1104-11.
In burn patients, MRSA was detected in the wound from the early stage to the wound closure stage. It is after the middle stage that sepsis by MRSA occurs. In comparison with Gram-negative bacilli, MRSA caused fewer sudden deaths, except for complications of toxic shock syndrome (TSS); MRSA was not considered to have a significant effect. The presence of a path of invasion into the blood other than the wound was suspected. Investigation of 35 Staphylococcus aureus sepsis patients (25 infected with MRSA) revealed that diagnosis is difficult when severe TSS occurs as a complication in sepsis. No correlation was found between toxic shock syndrome toxin-1 production by the bacterium detected and the onset of TSS. These findings suggest strong dependency upon the action of another toxin or endotoxin produced by Staphylococcus aureus and upon the immune condition of the host.
在烧伤患者中，从伤口早期到伤口闭合阶段都能检测到耐甲氧西林金黄色葡萄球菌（MRSA）。MRSA引起的败血症发生在中期之后。与革兰氏阴性杆菌相比，除中毒性休克综合征（TSS）并发症外，MRSA导致的猝死较少；人们认为MRSA没有显著影响。怀疑存在除伤口外的血液入侵途径。对35例金黄色葡萄球菌败血症患者（25例感染MRSA）的调查显示，当败血症并发严重TSS时，诊断困难。所检测细菌产生的中毒性休克综合征毒素-1与TSS的发作之间未发现相关性。这些发现表明，其强烈依赖于金黄色葡萄球菌产生的另一种毒素或内毒素的作用以及宿主的免疫状况。
