Maruyama Shoji, Okabe Satoshi, Endo Mitsuo, Sato Kenji, Iwai Takehisa
Department of Surgery, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
J Med Dent Sci. 2003 Dec;50(4):275-84.
The parasympathetic nerves regulate colonic motility and defecation. The vagal nerve controls the right colon and the pelvic nerve permeates the left colon and rectum via the rectal branches of the pelvic plexus (RBPP). This investigation aimed to measure the functional changes of the colon and rectum after RBPP-transection for over six months. RBPP-transection was performed in 15 dogs. Five dogs each were sacrificed immediately, one month, and six months after RBPP-transection. The stool condition, colorectal transit, defecation reflex, colorectal response to electrical stimulation, and pathological degeneration was investigated prior to, one month after, and six months after RBPP-transection. Four of the 5 dogs observed had loose stool one month after RBPP-transection, and one of the 3 had recovered six months later. Half transit time (HTT) at transverse colon got longer in six of the 8 in one month. Six months later, HTT got shorter in three of the 4 than that of one month. Defecation reflex was not observed one month after RBPP-transection, but noted in two of the 5 six months later. These results may suggest that vagal nerve compensates for the oral site of the left colon after denervation of the pelvic nerve which is originally distributed.
副交感神经调节结肠运动和排便。迷走神经控制右半结肠，而盆神经通过盆丛直肠支（RBPP）支配左半结肠和直肠。本研究旨在测量RBPP横断超过六个月后结肠和直肠的功能变化。对15只犬进行RBPP横断。分别在RBPP横断后即刻、1个月和6个月处死5只犬。在RBPP横断前、横断后1个月和6个月，对粪便状况、结直肠转运、排便反射、结直肠对电刺激的反应以及病理退变进行研究。观察的5只犬中有4只在RBPP横断后1个月出现稀便，3只中有1只在6个月后恢复。1个月时，8只中的6只横结肠的半程转运时间（HTT）延长。6个月后，4只中的3只HTT比1个月时缩短。RBPP横断后1个月未观察到排便反射，但6个月后5只中有2只出现排便反射。这些结果可能提示，在原本分布的盆神经去神经支配后，迷走神经可代偿左半结肠的近端部位。
