单克隆丙种球蛋白病患者中本-周蛋白尿检测的新概念。
A new concept for detection of Bence Jones proteinuria in patients with monoclonal gammopathy.
作者信息
Hofmann Walter, Garbrecht Manfred, Bradwell Arthur R, Guder Walter G
机构信息
Institut Klinische Chemie und Immunologie, Städlisches Krankenhaus München-Neuperlach, Germany.
出版信息
Clin Lab. 2004;50(3-4):181-5.
Bence Jones (free light chain-FLC) proteinuria is usually detected by immunofixation electrophoresis (IFE) of urine. With a new, automated immunoassay, it is now possible to quantify FLC in serum and urine. In the present study, we compared different routine methods for monoclonal FLC screening. From our results we conclude that the measurement of FLC in serum is highly sensitive and should replace urine tests. Additionally, possible kidney dysfunction, caused by nephrotoxicity of FLC, should be assessed by urine protein analysis and cystatin C measurements.
本周氏蛋白（游离轻链-FLC）蛋白尿通常通过尿液免疫固定电泳（IFE）检测。借助一种新型自动化免疫测定法，现在能够对血清和尿液中的FLC进行定量。在本研究中，我们比较了不同的单克隆FLC筛查常规方法。根据我们的结果，我们得出结论，血清中FLC的测量高度敏感，应取代尿液检测。此外，由FLC肾毒性引起的可能的肾功能障碍，应通过尿蛋白分析和胱抑素C测量进行评估。
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