Renal Institute of Birmingham, University Hospital Birmingham, and Department of Infection and Immunity, University of Birmingham, Birmingham, UK.
Nat Rev Nephrol. 2009 Nov;5(11):621-8. doi: 10.1038/nrneph.2009.151. Epub 2009 Sep 29.
Abnormalities of immunoglobulin free light chains (FLCs) are frequently present in patients with monoclonal gammopathies and can cause kidney disease. The recent introduction of highly sensitive immunoassays that measure FLCs to levels below those present in normal individuals has provided a new tool for diagnosis and management in this setting. Here, we review the biology of FLC production in health and disease, and the utility of FLC immunoassays in the assessment of monoclonal gammopathies in kidney disease.
免疫球蛋白游离轻链（FLC）的异常经常出现在单克隆丙种球蛋白病患者中，并可导致肾脏疾病。最近引入的高灵敏度免疫分析方法可以检测到低于正常人水平的 FLC，为这种情况下的诊断和治疗提供了新的工具。在这里，我们回顾了 FLC 在健康和疾病中的产生生物学，以及 FLC 免疫分析在肾脏疾病中单克隆丙种球蛋白病评估中的应用。
