Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Am J Hematol. 2010 Oct;85(10):787-90. doi: 10.1002/ajh.21815.
In a variety of hematologic malignancies, immunoglobulin light chains (LC) are overproduced clonally and circulate without being linked by disulphide bonds to the immunoglobulin heavy chain. The recent development of a robust assay known as κ and λ "free" LC (FLC) to quantify the levels of these unbound LC in the serum, and thereby determine their ratio, has led to an explosion of studies that demonstrate its utility in a wide range of hematologic disorders. This article summarizes laboratory testing for serum FLC, with a particular focus on clinical applications for the test.
在各种血液恶性肿瘤中，免疫球蛋白轻链（LC）异常克隆性产生，且不通过二硫键与免疫球蛋白重链连接而循环。最近开发了一种强大的检测方法，称为κ和λ“游离”轻链（FLC），用于定量检测血清中这些未结合的 LC 水平，并确定其比值，这导致了大量研究，证明了其在广泛的血液系统疾病中的应用。本文总结了血清 FLC 的实验室检测，特别关注该检测的临床应用。
