吲哚-2-酮衍生物对化合物48/80诱导的肥大细胞组胺释放的抑制活性。
Inhibitory activity of indolin-2-one derivatives on compound 48/80-induced histamine release from mast cells.
作者信息
Rüster G U, Hoffmann B, Hamburger M
机构信息
Institute of Pharmacy, Friedrich-Schiller-University, Jena, Germany.
出版信息
Pharmazie. 2004 Mar;59(3):236-7.
PMID:15074604
Abstract
Four alkaloids, previously identified in Isatis species, were tested for their inhibitory effect on histamine release. Whereas tryptanthrin, indirubin and deoxyvasicinone did not inhibit histamine release, the effect of indolin-2-one exceeded that of the mast cell stabilizing drug disodium chromoglycate.
摘要
对之前在菘蓝属植物中鉴定出的四种生物碱进行了组胺释放抑制作用测试。其中，色胺酮、靛玉红和去氧瓦西酮对组胺释放没有抑制作用，而吲哚-2-酮的效果超过了肥大细胞稳定剂色甘酸二钠。
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