Anderson R C, Hume M E, Genovese K J, Callaway T R, Jung Y S, Edrington T S, Poole T L, Harvey R B, Bischoff K M, Nisbet D J
United States Department of Agriculture, Agricultural Research Service, Southern Plains Agricultural Research Center, Food and Feed Safety Research Unit, 2881 F&B Road, College Station, TX 77845, USA.
Vet Res Commun. 2004 Apr;28(3):179-89. doi: 10.1023/b:verc.0000017369.04003.2b.
Foodborne disease caused by Salmonella is of public health and economic significance. In order to assess the practical effectiveness of a new intervention strategy, experimental chlorate preparations (ECP) were administered via the drinking water to weaned and finished pigs that had been orally challenged the previous day with 10(9)-10(10) colony-forming units of Salmonella serovar Typhimurium. After 24 or 36 h ad libitum access to 0X, 1X or 2X ECP treatment (where X is the concentration estimated to deliver a minimal daily effective dose), the pigs were euthanized and gut contents and lymph tissue collected at necropsy were cultured for the challenge Salmonella. Drinking water administration of ECP effectively reduced (p < 0.05) caecal Salmonella concentrations and, with the weaned pigs, tended (p < or = 0.10) to reduce rectal Salmonella concentrations. No negative effects of ECP treatment on water intake and animal wellbeing were observed and only marginal effects on gut fermentation characteristics occurred. The bactericidal effect of administering ECP in drinking water was relatively rapid, with reductions in caecal Salmonella concentrations occurring within 24 h. These results suggest that ECP administered to pigs just days before slaughter may reduce gut concentrations of Salmonella; however, the impacts of such reductions on slaughter hygiene have yet to be determined.
由沙门氏菌引起的食源性疾病具有公共卫生和经济意义。为了评估一种新干预策略的实际效果，将实验性氯酸盐制剂（ECP）通过饮用水给予前一天经口服感染了10⁹ - 10¹⁰个鼠伤寒沙门氏菌菌落形成单位的断奶仔猪和育肥猪。在随意饮用0X、1X或2X ECP处理的水24或36小时后（其中X是估计能提供每日最小有效剂量的浓度），对猪实施安乐死，并在尸检时收集肠道内容物和淋巴组织，用于培养挑战沙门氏菌。通过饮用水给予ECP有效降低了（p < 0.05）盲肠沙门氏菌浓度，对于断奶仔猪，还倾向于（p ≤ 0.10）降低直肠沙门氏菌浓度。未观察到ECP处理对水摄入量和动物健康有负面影响，且对肠道发酵特性仅有轻微影响。通过饮用水给予ECP的杀菌效果相对较快，在24小时内盲肠沙门氏菌浓度就有所降低。这些结果表明，在屠宰前几天对猪施用ECP可能会降低肠道沙门氏菌浓度；然而，这种降低对屠宰卫生的影响尚未确定。
