Haneda M, Kikkawa R, Ebata K, Sugimoto T, Shigeta Y
3rd Department of Medicine, Shiga University of Medical Science, Otsu.
Rinsho Byori. 1992 Jul;40(7):692-6.
To clarify the problem in the measurement of renal plasma flow and glomerular filtration rates in diabetes, the effect of glucose on the determination of para-aminohippuric acid (PAH) and inulin was examined. The concentration of urinary PAH in glucosuric diabetic subjects decreased after the storage of urine samples because of the glycation of PAH. Therefore, glucose must be removed by the acid treatment before the determination of the concentrations of urinary PAH. Since glucose can interfere with the assay of inulin, the sample must be treated with NaOH prior to the determination of the inulin concentration. GFR of the subjects with type 2 diabetes was next examined. GFR in the subjects with a duration of diabetes less than 10 years was significantly higher than that in the subjects with a duration of diabetes more than 10 years. Thus, the subjects with short-term type 2 diabetes may present with hyperfiltration similar to the subjects with short-term type 1 diabetes.
为了阐明糖尿病患者肾血浆流量和肾小球滤过率测量中的问题，研究了葡萄糖对对氨基马尿酸（PAH）和菊粉测定的影响。由于PAH的糖基化作用，糖尿病人尿液样本储存后尿中PAH浓度降低。因此，在测定尿中PAH浓度之前，必须通过酸处理去除葡萄糖。由于葡萄糖会干扰菊粉的测定，在测定菊粉浓度之前，样本必须用NaOH处理。接下来检查了2型糖尿病患者的肾小球滤过率。糖尿病病程小于10年的患者的肾小球滤过率显著高于病程超过10年的患者。因此，短期2型糖尿病患者可能会出现与短期1型糖尿病患者类似的高滤过状态。
