Choudhary Muhammad Iqbal, Ranjit Rosa, Atta-Ur-Rahman Atta-Ur-Rahman, Shrestha Tirtha Maiya, Yasin Amsha, Parvez Masood
H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
J Org Chem. 2004 Apr 16;69(8):2906-9. doi: 10.1021/jo030337u.
A novel sesterterpene, leucosceptrine, was isolated from the medicinal plant Leucosceptrum canum from Nepal. The structure was determined by single-crystal X-ray diffraction and spectroscopic techniques. The biosynthesis of leucosceptrine (1) is proposed here. Leucosceptrine (1) exhibited prolylendopeptidase inhibitory activity.
从尼泊尔的药用植物白绒草中分离出一种新型的倍半萜烯——白绒草碱。其结构通过单晶X射线衍射和光谱技术确定。本文提出了白绒草碱（1）的生物合成途径。白绒草碱（1）具有脯氨酰内肽酶抑制活性。
