双硫仑连续治疗可抑制大鼠卵巢羰基还原酶活性。
Consecutive treatment of disulfiram inhibits ovarian carbonyl reductase activity in rats.
作者信息
Iwata N, Inazu N, Satoh T
机构信息
Division of Xenobiotic Metabolism and Disposition, National Institute of Hygienic Sciences, Tokyo, Japan.
出版信息
Jpn J Pharmacol. 1992 Feb;58(2):167-73. doi: 10.1254/jjp.58.167.
We investigated the effects of disulfiram (DS) on ovarian carbonyl reductase activity in rats to determine the influence of DS on female reproductive function. Three consecutive treatments with DS significantly inhibited ovarian carbonyl reductase activity as well as ovulation, dose-dependently. Single treatment with DS had no effect on ovarian carbonyl reductase activity. Our observations indicate that consecutive treatment with DS has an inhibitory action on female reproductive function, although DS is well-known to inhibit aldehyde dehydrogenase and dopamine beta-hydroxylase.
我们研究了双硫仑（DS）对大鼠卵巢羰基还原酶活性的影响，以确定DS对雌性生殖功能的影响。连续三次给予DS可显著抑制卵巢羰基还原酶活性以及排卵，且呈剂量依赖性。单次给予DS对卵巢羰基还原酶活性无影响。我们的观察结果表明，连续给予DS对雌性生殖功能有抑制作用，尽管众所周知DS可抑制醛脱氢酶和多巴胺β-羟化酶。
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