Inaba N, Inazu N, Kogo H, Satoh T
Department of Pharmacology and Toxicology, Tokyo College of Pharmacy, Japan.
Jpn J Pharmacol. 1991 May;56(1):61-9. doi: 10.1254/jjp.56.61.
The pharmacological effects of antiestrogens on ovarian aldo-keto reductase and ovulation were investigated in rats. The activities of reduction of 13,14-dihydro-15-keto-PGF2 alpha, 4-benzoylpyridine and menadione in ovarian cytosol were significantly decreased by antiestrogen treatments, and the ovulation was completely inhibited. However, administration of luteinizing hormone-releasing hormone at 3:00 p.m. on the day of proestrus restored both enzyme activities and ovulation, which were inhibited by antiestrogens, to control levels. These results indicate that nonsteroidal antiestrogen inhibits the luteinizing hormone surge on the day of proestrus in 4-day cycling rats and that ovarian aldo-keto reductase may be closely involved in the ovulatory process in rats.
在大鼠中研究了抗雌激素对卵巢醛糖酮还原酶和排卵的药理作用。抗雌激素处理显著降低了卵巢胞质溶胶中13,14-二氢-15-酮-PGF2α、4-苯甲酰吡啶和甲萘醌的还原活性，并且排卵被完全抑制。然而，在动情前期当天下午3点给予促黄体生成素释放激素可将被抗雌激素抑制的酶活性和排卵恢复至对照水平。这些结果表明，非甾体类抗雌激素抑制4天周期大鼠动情前期当天的促黄体生成素激增，并且卵巢醛糖酮还原酶可能与大鼠的排卵过程密切相关。
