Eley Thalia C, Liang Holan, Plomin Robert, Sham Pak, Sterne Abram, Williamson Richard, Purcell Shaun
Institute of Psychiatry, King's College London, UK.
J Am Acad Child Adolesc Psychiatry. 2004 Mar;43(3):298-306. doi: 10.1097/00004583-200403000-00011.
Familial risk for depression results from both biological and social influences. These may also be associated with other characteristics, including alcohol use, smoking, and body mass index (BMI), and with environmental risks such as social problems, life events, and educational level, all of which may be associated with depression in offspring. The authors examined the links between (1) parental familial vulnerability to depression and (2) the role of associated parental characteristics on severe adolescent depressive symptoms. Third, the authors explored the influence of family environment variables. Fourth, the authors sought interactions between parental familial vulnerability and family environment.
Questionnaires were obtained from 1,294 parents of 1,818 adolescent offspring.
The odds of severe adolescent depressive symptoms increased by a factor of 1.5 per standard deviation increase in parental familial vulnerability to depression (odds ratio [OR] = 1.50). Parental BMI (OR = 1.05) and educational level (OR = 2.60) had significant influences independent of parental vulnerability. Analyses indicated a significant interaction such that those with high parental familial vulnerability, whose parents also had no qualifications, had a threefold risk of severe depressive symptoms.
Adolescents with a family history of depression whose parents also lack qualifications may be a target for intervention.
抑郁症的家族风险源于生物和社会影响。这些影响可能还与其他特征有关，包括饮酒、吸烟和体重指数（BMI），以及社会问题、生活事件和教育水平等环境风险，所有这些都可能与后代的抑郁症有关。作者研究了（1）父母的家族抑郁症易感性与（2）相关父母特征对青少年严重抑郁症状的作用之间的联系。第三，作者探讨了家庭环境变量的影响。第四，作者探寻了父母的家族易感性与家庭环境之间的相互作用。
从1818名青少年后代的1294名父母那里获取了调查问卷。
父母的家族抑郁症易感性每增加一个标准差，青少年出现严重抑郁症状的几率就会增加1.5倍（优势比[OR]=1.50）。父母的BMI（OR=1.05）和教育水平（OR=2.60）在不考虑父母易感性的情况下有显著影响。分析表明存在显著的相互作用，即父母家族易感性高且父母又没有学历的青少年出现严重抑郁症状的风险是三倍。
有抑郁症家族史且父母又没有学历的青少年可能是干预的目标对象。
