Jiang Chong-He, Hermanson Ola
Department of Biomedicine and Surgery, Linköping University, SE-581 85 Linköping, Sweden.
Neuroreport. 2004 Feb 9;15(2):351-5. doi: 10.1097/00001756-200402090-00028.
Although visceral innocuous cold receptors have been documented, the central termination of their afferents is unknown. We used menthol solution (0.6 mM) to obtain selective activation of cold receptors in the urinary bladder of rats. Innocuous cold stimulation induced Fos expression in a population of neurons in the superficial dorsal horn of L6-S1 segments of the spinal cord. Neurons in other regions of the spinal cord, e.g. the lumbar parasympathetic nucleus or the dorsal commissure region, were activated to a similar degree by menthol and control infusions, indicating a response to bladder filling. Our results are consistent with the proposal that subsets of modality-specific dorsal horn neurons convey specific information regarding the exteroceptive and interoceptive state of the animal.
虽然内脏无害冷感受器已被记录，但它们的传入神经在中枢的终止位置尚不清楚。我们使用薄荷醇溶液（0.6 mM）来选择性激活大鼠膀胱中的冷感受器。无害冷刺激诱导脊髓L6 - S1节段浅表背角一群神经元中Fos的表达。脊髓其他区域的神经元，如腰段副交感神经核或背连合区，薄荷醇灌注和对照灌注对其激活程度相似，表明是对膀胱充盈的反应。我们的结果与以下观点一致，即特定模态的背角神经元亚群传达有关动物外感受和内感受状态的特定信息。
