Kassubek Jan, Bernhard Landwehrmeyer G, Ecker Daniel, Juengling Freimut D, Muche Rainer, Schuller Sabine, Weindl Adolf, Peinemann Alexander
Department of Neurology, University of Ulm, Germany.
Neuroreport. 2004 Feb 9;15(2):363-5. doi: 10.1097/00001756-200402090-00030.
Global brain atrophy was determined in 70 patients suffering from Huntington's disease (HD) and 70 healthy controls, using brain parenchymal fractions calculated from 3D MRI data in a standardized procedure. In HD patients, brain parenchymal fractions were significantly reduced compared to controls in all age groups; the physiological decline with age was less pronounced in HD. However, brain parenchymal fraction values did not allow the prediction of clinical impairment (as assessed by clinical scores). Global brain parenchyma reduction seems to be an early or even constitutional feature of HD, but clinical symptoms appear to reflect regional rather than global atrophy. Overall, MRI-based brain volume quantification correlated with clinical scores clarifies the functional impact of morphological brain alterations.
采用标准化程序，根据3D MRI数据计算脑实质分数，对70例亨廷顿舞蹈症（HD）患者和70名健康对照者进行全脑萎缩测定。在HD患者中，各年龄组的脑实质分数均显著低于对照组；HD患者随年龄增长的生理性衰退不那么明显。然而，脑实质分数值无法预测临床损伤（通过临床评分评估）。全脑实质减少似乎是HD的早期甚至是先天性特征，但临床症状似乎反映的是局部而非全脑萎缩。总体而言，基于MRI的脑容量量化与临床评分的相关性阐明了脑形态改变的功能影响。
