Bertram B, Wolf S, Arend O, Schulte K, Reim M
Augenklinik, RWTH Aachen.
Klin Monbl Augenheilkd. 1992 Jun;200(6):654-7. doi: 10.1055/s-2008-1045851.
In 42 type II diabetic patients with nonproliferative diabetic retinopathy the arm-retina time (ART) and arteriovenous passage time (AVP) were measured by means of videofluorescein angiography. Glycosylated hemoglobin (HbAlc) as a parameter of longterm diabetic control and the blood glucose level were determined. The ART in the diabetics was similar to the ART of normals and the AVP was significantly prolonged. HbAlc level ranged between 5.6 and 12.2% (8.6 +/- 1.7%) and the blood glucose level between 4.5 and 22.9 mmol/l (11.4 +/- 4.5 mmol/l). Significant correlations were found between AVP and blood glucose (r = 0.37) and between AVP and HbAlc (r = 0.49). No correlation was found neither between ART and blood glucose nor between ART and HbAlc. A multiple stepwise regression analysis shows that of both investigated parameters HbAlc is the predicting variable for AVP. These results show that in diabetic patients the retinal blood flow is more influenced by the longterm diabetic control than by the blood glucose level at the time of examination.
在42例患有非增殖性糖尿病视网膜病变的II型糖尿病患者中，通过视频荧光血管造影术测量了手臂-视网膜时间（ART）和动静脉通过时间（AVP）。测定了糖化血红蛋白（HbAlc）作为长期糖尿病控制的参数以及血糖水平。糖尿病患者的ART与正常人的ART相似，而AVP显著延长。HbAlc水平在5.6%至12.2%之间（8.6±1.7%），血糖水平在4.5至22.9 mmol/L之间（11.4±4.5 mmol/L）。发现AVP与血糖之间存在显著相关性（r = 0.37），AVP与HbAlc之间也存在显著相关性（r = 0.49）。未发现ART与血糖之间以及ART与HbAlc之间存在相关性。多元逐步回归分析表明，在所研究的两个参数中，HbAlc是AVP的预测变量。这些结果表明，在糖尿病患者中，视网膜血流受长期糖尿病控制的影响比受检查时血糖水平的影响更大。
