Shirinian E A, Arutiunian S A, Petrosian A A, Gevorkian G A, Markarian E A, Vartanian S O, Medvedev O S, Garibdzhanian B T
Laboratory of Pharmacology of Cardiovascular Drugs, Institute of Fine Organic Chemistry, National Academy of Sciences of the Republic of Armenia, Azatutyan pr. 26, Yerevan, 375014 Armenia.
Eksp Klin Farmakol. 2004 Jan-Feb;67(1):11-4.
In rats with a hemodynamic disorder caused by acute myocardial ischemia, preliminary administration of beditin in a dose of 25 mg/kg fully prevents a manifold increase in the level of 45Ca2+ in the cytosol of brain cells and leads to enhanced trapping and accumulation of labeled calcium in endoplasmic reticulum. With respect to calcium binding in endoplasmic reticulum, the action of beditin substantially differs from that of verapamil.
在由急性心肌缺血引起血流动力学紊乱的大鼠中，预先给予25毫克/千克剂量的贝迪汀可完全防止脑细胞胞质溶胶中45Ca2+水平的大幅升高，并导致内质网中标记钙的捕获和积累增强。关于内质网中的钙结合，贝迪汀的作用与维拉帕米的作用有很大不同。
