Dzhanpoladian E G, Samvelian V M, Arutiunian S A, Shirinian E A
Eksp Klin Farmakol. 1996 Sep-Oct;59(5):21-2.
In experiments on rats with acute myocardial infarction induced by occlusion of the left coronary artery in conscious animals the protective effect of verapamil on the heart, brain, liver, and kidneys in this disease was studied. The effectiveness of the drug was judged by the changes in the 45Ca2+ content in the intracellular structures (cytosol, mitochondria, endoplasmic reticulum) of the organs under study. A single injection of 200 micrograms/kg verapamil in acute myocardial infarction reduces considerably the content of 45Ca2+ in the intracellular structures of these organs and thus prevents the development of pathological processes.
在清醒动物中通过左冠状动脉闭塞诱导急性心肌梗死的大鼠实验中，研究了维拉帕米对该疾病心脏、大脑、肝脏和肾脏的保护作用。通过所研究器官细胞内结构（细胞溶质、线粒体、内质网）中45Ca2+含量的变化来判断药物的有效性。在急性心肌梗死中单次注射200微克/千克维拉帕米可显著降低这些器官细胞内结构中45Ca2+的含量，从而防止病理过程的发展。
