Zhu Peiyuan, Ma Yuping, Huang Yufeng
Laboratory of Reproduction & Genetics, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
Zhonghua Nan Ke Xue. 2004 Mar;10(3):222-6.
The sperm DNA integrity is important for the success of natural or assisted fertilization, as well as normal development of the embryo, fetus and child. Some investigations have demonstrated that when the damaged spermatozoa DNA of the husband exceeds than 30%, the couple has very low potential of natural fertility. Several methods are available for the assessment of sperm DNA integrity, which is considered to be a better marker of male fertility potential than conventional semen parameters. Furthermore, monitering sperm DNA integrity may become an important part of the evaluation for couples seeking assisted reproductive techniques such as intracytoplasmic sperm injection (ICSI). Finally, the effects of cryopreservation and preparation techniques on sperm DNA integrity are summarized.
精子DNA完整性对于自然受精或辅助受精的成功以及胚胎、胎儿和儿童的正常发育都很重要。一些研究表明，当丈夫受损精子DNA超过30%时，这对夫妇自然生育的可能性非常低。有几种方法可用于评估精子DNA完整性，它被认为是比传统精液参数更好的男性生育潜力标志物。此外，监测精子DNA完整性可能会成为寻求诸如卵胞浆内单精子注射（ICSI）等辅助生殖技术的夫妇评估的重要组成部分。最后，总结了冷冻保存和制备技术对精子DNA完整性的影响。
