Lebedová V, Krízová P
NRL for Haemophilus Infections, National Institute of Public Health, Prague, Czech Republic.
Cent Eur J Public Health. 2003 Dec;11 Suppl:S25-30.
Dynamics in total antibody levels against Haemophilus influenzae b (Hib) among the Czech population were monitored for the first time within the 2001 serological survey. In total, 2,479 non-vaccinee sera and 65 vaccinee sera from the population of age groups 1-39 years were tested. The total anti-Hib antibody levels determined by means of ELISA were higher than 0. 15 microg/ml for all of the sera tested. Levels of 1 microg/ml or higher were recorded for 97% and 99% of vaccinee and non-vaccinee sera, respectively. The non-vaccinees showed the highest rates of levels below 1 microg/ml in the age groups of 1-, 2-, 6- and 12-year-olds (4%, 7%, 3% and 3%, respectively). Only one child aged 1 year had a level below 1 microg/ml among the vaccinees. Levels of 2 microg/ml and higher were found in 89% and 91% of non-vaccinee and vaccinee sera, respectively. The non-vaccinees showed the highest rates of levels below 2 microg/ml in the age groups of 1-, 2-, 3-, 4- and 6-year-olds (46%, 37%, 22%, 20% and 18%, respectively), the other age groups were characterized by lower rates (2-13%). Levels below 2 microg/ml were found in 1-, 2-, and 4-year-old vaccinees (25%, 4% and 9%, respectively). In conclusion, it can be stated that the immunity of most of the Czech population is very good. Nevertheless, children under 6 years of age are at highest risk as also confirmed by the programme of Hib invasive disease surveillance. As many as 94 cases of Hib invasive diseases were recorded in the Czech Republic in 2001, 82 (87%) of them in children aged between 0 to 6 years, with only sporadic cases being detected in the other age groups.
2001年血清学调查首次对捷克人群中抗b型流感嗜血杆菌（Hib）的总抗体水平动态进行了监测。总共检测了年龄在1至39岁人群中的2479份未接种疫苗者的血清和65份接种疫苗者的血清。通过酶联免疫吸附测定法测定的所有检测血清的抗Hib总抗体水平均高于0.15微克/毫升。接种疫苗者和未接种疫苗者的血清中，分别有97%和99%的血清记录到1微克/毫升或更高的水平。在1岁、2岁、6岁和12岁年龄组的未接种疫苗者中，低于1微克/毫升水平的比例最高（分别为4%、7%、3%和3%）。在接种疫苗者中，只有一名1岁儿童的水平低于1微克/毫升。分别在89%和91%的未接种疫苗者和接种疫苗者的血清中发现了2微克/毫升及更高的水平。在1岁、2岁、3岁、4岁和6岁年龄组的未接种疫苗者中，低于2微克/毫升水平的比例最高（分别为46%、37%、22%、20%和18%），其他年龄组的比例较低（2%至13%）。在1岁、2岁和4岁的接种疫苗者中发现了低于2微克/毫升的水平（分别为25%、4%和9%）。总之，可以说大多数捷克人群的免疫力非常好。然而，6岁以下儿童面临的风险最高，Hib侵袭性疾病监测计划也证实了这一点。2001年捷克共和国记录了多达94例Hib侵袭性疾病病例，其中82例（87%）发生在0至6岁的儿童中，其他年龄组仅检测到散发病例。
