Talpur Nadeem, Echard Bobby, Dadgar Azod, Aggarwal Sarla, Zhuang Cun, Bagchi Debasis, Preuss Harry G
Department of Physiology, Medicine and Pathology, Georgetown University Medical Center, Washington, DC 20057, USA.
Res Commun Mol Pathol Pharmacol. 2002;112(1-4):68-82.
A link exists between insulin resistance and many chronic disorders of aging including advancing-age. A safer means to prevent or, at least, slow the erosion of insulin sensitivity would provide a novel approach to better health. We compared the ability of a specific extract labeled fraction SX, as well as whole Maitake powder, fraction ES and fraction D of Maitake to influence SBP and various pertinent biochemical parameters when given orally to Zucker Fatty rats, a model of insulin resistance and type 2 diabetes mellitus. A secondary gain was the ability to ascertain the effects of bitter melon, olive oil, and sesame oil alone and combined with fraction SX to influence SBP. We found that a water-soluble fraction obtained from Maitake mushroom (SX) lowers SBP and fasting blood glucose significantly over the three to six weeks of study. While whole Maitake fraction lowered SBP effectively, the effects on fasting blood sugar were not apparent under the conditions of study. In contrast to fraction SX and fraction D, developed primarily to enhance immunity and suppress tumor development and growth, has essentially no effect on SBP under the conditions examined. An ether soluble fraction designated ES lowers SBP significantly. Interestingly, olive oil, unlike sesame oil, also lowers SBP. Finally, bitter melon and a combination of SX plus bitter melon also lower SBP. We conclude that fraction SX of Maitake mushroom may be useful to treat insulin resistance alone or combined with other natural products such as bitter melon and niacin-bound chromium.
胰岛素抵抗与包括衰老在内的许多慢性衰老疾病之间存在联系。一种更安全的预防方法，或者至少减缓胰岛素敏感性下降的方法，将为改善健康提供一种新途径。我们比较了一种特定的标记提取物SX部分，以及舞茸全粉、舞茸的ES部分和D部分，在口服给予Zucker肥胖大鼠（一种胰岛素抵抗和2型糖尿病模型）时，对收缩压（SBP）和各种相关生化参数的影响。另一个收获是能够确定单独的苦瓜、橄榄油和芝麻油，以及与SX部分联合使用时对SBP的影响。我们发现，从舞茸中获得的一种水溶性部分（SX）在三到六周的研究中显著降低了SBP和空腹血糖。虽然舞茸全粉部分有效地降低了SBP，但在研究条件下对空腹血糖的影响并不明显。与主要用于增强免疫力和抑制肿瘤发展与生长的SX部分和D部分不同，在所研究的条件下，D部分对SBP基本没有影响。一种名为ES的醚溶性部分显著降低了SBP。有趣的是，与芝麻油不同，橄榄油也能降低SBP。最后，苦瓜以及SX与苦瓜的组合也能降低SBP。我们得出结论，舞茸的SX部分可能单独用于治疗胰岛素抵抗，或与其他天然产物如苦瓜和烟酸结合铬联合使用。
