β-葡聚糖在糖尿病治疗及相关心血管风险中的应用
Beta-glucans in the treatment of diabetes and associated cardiovascular risks.
作者信息
Chen Jiezhong, Raymond Kenneth
机构信息
John Curtin School of Medical Research, Australian National University, Acton, ACT, Australia.
出版信息
Vasc Health Risk Manag. 2008;4(6):1265-72. doi: 10.2147/vhrm.s3803.
Abstract
Diabetes mellitus is characterized by high blood glucose level with typical manifestations of thirst, polyuria, polydipsia, and weight loss. It is caused by defects in insulin-mediated signal pathways, resulting in decreased glucose transportation from blood into muscle and fat cells. The major risk is vascular injury leading to heart disease, which is accelerated by increased lipid levels and hypertension. Management of diabetes includes: control of blood glucose level and lipids; and reduction of hypertension. Dietary intake of beta-glucans has been shown to reduce all these risk factors to benefit the treatment of diabetes and associated complications. In addition, beta-glucans also promote wound healing and alleviate ischemic heart injury. However, the mechanisms behind the effect of beta-glucans on diabetes and associated complications need to be further studied using pure beta-glucan.
摘要
糖尿病的特征是血糖水平升高，伴有口渴、多尿、多饮和体重减轻等典型症状。它是由胰岛素介导的信号通路缺陷引起的，导致血液中的葡萄糖向肌肉和脂肪细胞的转运减少。主要风险是血管损伤导致心脏病，而血脂升高和高血压会加速这一过程。糖尿病的管理包括：控制血糖水平和血脂；降低高血压。已证明饮食中摄入β-葡聚糖可降低所有这些风险因素，从而有利于糖尿病及其相关并发症的治疗。此外，β-葡聚糖还可促进伤口愈合并减轻缺血性心脏损伤。然而，需要使用纯β-葡聚糖进一步研究β-葡聚糖对糖尿病及其相关并发症影响的背后机制。
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