Talpur N, Echard B, Ingram C, Bagchi D, Preuss H
Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20057, USA.
Diabetes Obes Metab. 2005 Mar;7(2):193-9. doi: 10.1111/j.1463-1326.2004.00386.x.
Insulin resistance and its most severe form type 2 diabetes mellitus are rapidly increasing throughout the world. It is generally recognized that natural products with a long history of safety can increase insulin sensitivity.
The present investigation examined the ability of various combinations of essential oils such as fenugreek, cinnamon, cumin, oregano, etc. to enhance insulin sensitivity. As a first approximation, we examined the effects of these natural products on Zucker fatty rats (ZFRs), a model of obesity and insulin resistance, and spontaneously hypertensive rats (SHRs), a model of genetic hypertension.
Water or essential oils were given orally via droplets, and insulin sensitivity was estimated by systolic blood pressure (SBP) changes and circulating glucose and/or insulin concentrations.
We have found that the ability to alter SBP in rat models is the most sensitive early index of insulin sensitivity. The combined essential oils lowered circulating glucose levels and SBP in both ZFRs and SHRs, suggesting that these natural products are enhancing insulin sensitivity. The second series of studies examined two additional combinations of essential oils along with the original formula. The major differences were in the types and proportions of individual oils contributing to a given formula.
Although all the three formulae decreased SBP in ZFRs, one of the formulae was more effective than the others in lowering circulating glucose in the glucose tolerance testing. Accordingly, some essential oils may be added to the long list of natural products that can affect insulin sensitivity.
胰岛素抵抗及其最严重形式的2型糖尿病在全球范围内正迅速增加。人们普遍认识到，具有长期安全历史的天然产物可提高胰岛素敏感性。
本研究考察了葫芦巴、肉桂、小茴香、牛至等各种精油组合增强胰岛素敏感性的能力。作为初步近似研究，我们考察了这些天然产物对肥胖和胰岛素抵抗模型的Zucker肥胖大鼠（ZFRs）以及遗传性高血压模型的自发性高血压大鼠（SHRs）的影响。
通过滴注口服给予水或精油，通过收缩压（SBP）变化以及循环葡萄糖和/或胰岛素浓度评估胰岛素敏感性。
我们发现，在大鼠模型中改变SBP的能力是胰岛素敏感性最敏感的早期指标。组合精油降低了ZFRs和SHRs的循环葡萄糖水平和SBP，表明这些天然产物正在增强胰岛素敏感性。第二项系列研究考察了另外两种精油组合以及原始配方。主要差异在于构成给定配方的单一精油的类型和比例。
尽管所有三种配方均降低了ZFRs的SBP，但在葡萄糖耐量试验中，其中一种配方在降低循环葡萄糖方面比其他配方更有效。因此，一些精油可能会被添加到可影响胰岛素敏感性的天然产物的长长的列表中。
