Wiklund I, Holst J, Karlberg J, Mattsson L A, Samsioe G, Sandin K, Uvebrant M, von Schoultz B
Department of Medicine, Ostra Hospital, Göteborg, Sweden.
Maturitas. 1992 Mar;14(3):211-24. doi: 10.1016/0378-5122(92)90116-l.
An approach employing a range of standardized questionnaires, which included the Nottingham Health Profile (NHP), the Psychological General Well-Being (PGWB) index and the Mood Adjective Check List (MACL), was used to assess health-related quality of life (QoL) in conjunction with a study comparing two doses of transdermal oestrogen (50 or 100 micrograms/24 h) combined with an oral progestogen (5 mg medroxyprogesterone acetate for 14 days each cycle). In addition to the QoL measures, climacteric symptoms were self-rated and also summarized by means of the Kupperman index. In all, 59 women, median age 52 (39-71) years, who completed 4 months of therapy were evaluated. The use of a battery of standardized questionnaires enabled a comprehensive evaluation to be made of perceived health, well-being and day-to-day functioning. Not only was symptomatic relief, e.g. reduced frequency of sweating episodes, sleep disturbance and hot flushes, observed during treatment, but there were also improvements in terms of sleep, energy and emotions. The frequency of health-related problems associated with paid employment, housework, social life, home life and sex life decreased, indicating enhanced ability to take part in daily activities. The PGWB index showed improvement in the subscales representing well-being, anxiety, depression, vitality, health and self-control, while the mood scales indicated that the women experienced less tension and more satisfaction. Although the results of this study need to be further documented on the basis of a placebo-controlled trial, the findings nevertheless imply that the use of a battery of standardized questionnaires optimizes the possibility of evaluating climacteric complaints reliably before and after treatment.
采用一系列标准化问卷的方法来评估与健康相关的生活质量（QoL），这些问卷包括诺丁汉健康量表（NHP）、心理总体幸福感（PGWB）指数和情绪形容词检查表（MACL），该方法同时用于一项比较两种剂量经皮雌激素（50或100微克/24小时）与口服孕激素（每个周期14天服用5毫克醋酸甲羟孕酮）的研究。除了生活质量测量指标外，更年期症状由患者自评，并通过库珀曼指数进行汇总。共有59名年龄中位数为52（39 - 71）岁且完成了4个月治疗的女性接受了评估。使用一系列标准化问卷能够对感知到的健康、幸福感和日常功能进行全面评估。在治疗期间不仅观察到症状缓解，例如出汗发作频率降低、睡眠障碍和潮热减轻，而且在睡眠、精力和情绪方面也有改善。与有偿工作、家务、社交生活、家庭生活和性生活相关的健康问题频率降低，表明参与日常活动的能力增强。PGWB指数显示在代表幸福感、焦虑、抑郁、活力、健康和自我控制的子量表上有所改善，而情绪量表表明这些女性的紧张感减轻且满意度更高。尽管本研究的结果需要在安慰剂对照试验的基础上进一步记录，但这些发现仍然意味着使用一系列标准化问卷优化了在治疗前后可靠评估更年期症状的可能性。
