一些新型基于螺吲哚啉的杂环化合物作为潜在活性抗菌剂的合成与评价
Synthesis and evaluation of some new spiro indoline-based heterocycles as potentially active antimicrobial agents.
作者信息
Abdel-Rahman A H, Keshk E M, Hanna M A, el-Bady Sh M
机构信息
Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
出版信息
Bioorg Med Chem. 2004 May 1;12(9):2483-8. doi: 10.1016/j.bmc.2003.10.063.
Several new spiro indoline-based heterocycles were synthesized by prior preparation of the 4-(2'-oxo-indol-3'-ylidene)-oxazol-5-one derivatives and subsequent reaction of the produced indol-3-ylidene based heterocycles with activated nitrile reagents. The obtained products were allowed to react with hydrazine hydrate in alcoholic basic to give the target compounds. Structure of these products was confirmed on the bases of elemental as well as spectral data. Representative compounds of the hitherto synthesized products were tested and evaluated as antimicrobial agents.
通过预先制备4-(2'-氧代吲哚-3'-亚基)-恶唑-5-酮衍生物，然后使生成的基于吲哚-3-亚基的杂环与活性腈试剂反应，合成了几种新的基于螺吲哚啉的杂环化合物。将得到的产物在碱性醇溶液中与水合肼反应，得到目标化合物。根据元素分析和光谱数据确定了这些产物的结构。对迄今合成产物中的代表性化合物进行了测试和评估，以作为抗菌剂。
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