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新型多氮杂环化合物系统：合成、抗肿瘤和抗菌活性。

Novel polyazaheterocyclic systems: Synthesis, antitumor, and antimicrobial activities.

机构信息

Department of Chemistry, University of Cairo, Giza, Egypt.

出版信息

Arch Pharm Res. 2010 Nov;33(11):1721-8. doi: 10.1007/s12272-010-1102-8. Epub 2010 Nov 30.

DOI:10.1007/s12272-010-1102-8
PMID:21116773
Abstract

A series of new polyazaheterocyclic ring systems was synthesized via the reaction of enaminone 5 with active methylene compounds, hydrazine hydrate, hydroxylamine, and heterocyclic amines. The structures of the newly synthesized compounds were substantiated on the basis of spectral data and elemental analyses. The antitumor activity of the enaminone 5 against the human breast cell line MCF-7, the liver carcinoma cell line HEPG2-1, and HELA cells was determined. In addition, the antimicrobial activity of some selected products was evaluated.

摘要

通过烯胺酮 5 与活性亚甲基化合物、水合肼、羟胺和杂环胺的反应，合成了一系列新的多氮杂杂环环系。新合成化合物的结构是基于光谱数据和元素分析确定的。测定了烯胺酮 5 对人乳腺癌细胞系 MCF-7、肝癌细胞系 HEPG2-1 和 HELA 细胞的抗肿瘤活性。此外，还评价了一些选定产物的抗菌活性。

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