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恶唑衍生物生物活性的综合综述。

A comprehensive review on biological activities of oxazole derivatives.

作者信息

Kakkar Saloni, Narasimhan Balasubramanian

机构信息

Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001 India.

出版信息

BMC Chem. 2019 Feb 4;13(1):16. doi: 10.1186/s13065-019-0531-9. eCollection 2019 Dec.

Abstract

The utility of oxazole as intermediates for the synthesis of new chemical entities in medicinal chemistry have been increased in the past few years. Oxazole is an important heterocyclic nucleus having a wide spectrum of biological activities which drew the attention of researchers round the globe to synthesize various oxazole derivatives and screen them for their various biological activities. The present review article aims to review the work reported on therapeutic potentials of oxazole scaffolds which are valuable for medical applications during new millennium.

摘要

在过去几年中,恶唑作为药物化学中合成新化学实体的中间体的效用有所增加。恶唑是一种重要的杂环核,具有广泛的生物活性,这吸引了全球研究人员合成各种恶唑衍生物并对其各种生物活性进行筛选。本综述文章旨在回顾关于恶唑支架治疗潜力的报道工作,这些工作在新千年对医学应用具有重要价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608b/6661760/19a2e68dcd27/13065_2019_531_Fig1_HTML.jpg

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