Caillet-Fauquet Perrine, Di Giambattista Mario, Draps Marie-Louise, Sandras Flavienne, Branckaert Theo, de Launoit Yvan, Laub Ruth
Laboratoire de Virologie Moléculaire, Faculté de Médecine, Université Libre de Bruxelles, CP614, 808 route de Lennik, 1070 Brussels, Belgium.
J Virol Methods. 2004 Jun 15;118(2):131-9. doi: 10.1016/j.jviromet.2004.02.002.
Despite the increasing number of screening tests being introduced, ensuring the inactivation of blood-borne pathogens in blood-derived therapeutic material is a major concern. Dynamic continuous-flow UVC irradiation is a new way to inactivate a large range of pathogens without adding any photosentizers. The efficacy of different methods was evaluated against the following viruses: murine parvovirus MVMp, human B19, the encephalomyocarditis virus (EMC, a picornavirus used as a model for model for hepatitis A virus), and bovine herpes virus type 1 (BHV, a model for enveloped viruses such as hepatitis B virus). We show that continuous-flow UVC irradiation is very effective, particularly against resistant pathogens (e.g. parvoviruses and bacteria) at UVC doses preserving protein activity. It may be applicable to newly emerging related viruses or variants.
尽管引入的筛查检测数量不断增加，但确保血液衍生治疗材料中的血源性病原体失活仍是一个主要问题。动态连续流紫外线照射是一种在不添加任何光敏剂的情况下使多种病原体失活的新方法。针对以下病毒评估了不同方法的效果：小鼠细小病毒MVMp、人类B19、脑心肌炎病毒（EMC，一种用作甲型肝炎病毒模型的小RNA病毒）和牛疱疹病毒1型（BHV，一种用作乙型肝炎病毒等包膜病毒模型的病毒）。我们表明，连续流紫外线照射非常有效，特别是在保持蛋白质活性的紫外线剂量下，对耐药病原体（如细小病毒和细菌）尤其有效。它可能适用于新出现的相关病毒或变种。
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