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蛋白激酶Cζ亚型在非洲爪蟾卵母细胞成熟过程中作用的证据。

Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes.

作者信息

Dominguez I, Diaz-Meco M T, Municio M M, Berra E, García de Herreros A, Cornet M E, Sanz L, Moscat J

机构信息

Centro de Biología Molecular, CSIC-UAM, Madrid, Spain.

出版信息

Mol Cell Biol. 1992 Sep;12(9):3776-83. doi: 10.1128/mcb.12.9.3776-3783.1992.

DOI:10.1128/mcb.12.9.3776-3783.1992
PMID:1508183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC360243/
Abstract

A number of studies have demonstrated the activation of phospholipase C-mediated hydrolysis of phosphatidylcholine (PC-PLC) both by growth factors and by the product of the ras oncogene, p21ras. Evidence has been presented indicating that the stimulation of this phospholipid degradative pathway is sufficient to activate mitogenesis in fibroblasts as well as that it is sufficient and necessary for induction of maturation in Xenopus laevis oocytes. However, the mechanism whereby PC-PLC transduces mitogenic signals triggered by growth factors or oncogenes remains to be elucidated. In this study, data are presented that show the involvement of protein kinase C zeta subspecies in the channelling of the mitogenic signal activated by insulin-p21ras-PC-PLC in Xenopus oocytes as well as the lack of a critical role of protein kinase C isotypes alpha, beta, gamma, delta, and epsilon in these pathways.

摘要

多项研究已证明，生长因子和ras癌基因产物p21ras均可激活磷脂酶C介导的磷脂酰胆碱水解（PC-PLC）。已有证据表明，刺激这条磷脂降解途径足以激活成纤维细胞的有丝分裂，而且对于非洲爪蟾卵母细胞的成熟诱导来说，它也是充分必要的。然而，PC-PLC转导由生长因子或癌基因触发的有丝分裂信号的机制仍有待阐明。在本研究中，所呈现的数据表明，蛋白激酶C ζ亚型参与了非洲爪蟾卵母细胞中由胰岛素-p21ras-PC-PLC激活的有丝分裂信号的传递，并且蛋白激酶C α、β、γ、δ和ε亚型在这些途径中没有关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b363/360243/c675725fc88c/molcellb00132-0124-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b363/360243/323d933ac8c8/molcellb00132-0122-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b363/360243/77a922b20e40/molcellb00132-0124-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b363/360243/c675725fc88c/molcellb00132-0124-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b363/360243/323d933ac8c8/molcellb00132-0122-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b363/360243/77a922b20e40/molcellb00132-0124-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b363/360243/c675725fc88c/molcellb00132-0124-b.jpg

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Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes.蛋白激酶Cζ亚型在非洲爪蟾卵母细胞成熟过程中作用的证据。
Mol Cell Biol. 1992 Sep;12(9):3776-83. doi: 10.1128/mcb.12.9.3776-3783.1992.
2
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5
Evidence for different signalling pathways of PKC zeta and ras-p21 in Xenopus oocytes.非洲爪蟾卵母细胞中蛋白激酶Cζ和ras-p21不同信号通路的证据。
Oncogene. 1995 Oct 19;11(8):1541-7.
6
Diacylglycerol generated by exogenous phospholipase C activates the mitogen-activated protein kinase pathway independent of Ras- and phorbol ester-sensitive protein kinase C: dependence on protein kinase C-zeta.外源性磷脂酶C产生的二酰甘油激活丝裂原活化蛋白激酶途径，该途径独立于Ras和佛波酯敏感的蛋白激酶C：依赖于蛋白激酶C-ζ 。
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