蛋白激酶C的分子异质性及其对细胞调节的影响。
The molecular heterogeneity of protein kinase C and its implications for cellular regulation.
作者信息
Nishizuka Y
机构信息
Department of Biochemistry, Kobe University School of Medicine, Japan.
出版信息
Nature. 1988 Aug 25;334(6184):661-5. doi: 10.1038/334661a0.
DOI:10.1038/334661a0
PMID:3045562
Abstract
Protein kinase C is now known to be a large family of proteins, with multiple subspecies that have subtle individual enzymological characteristics. Some members of the family exhibit distinct patterns of tissue expression and intracellular localization; different kinases probably have distinct functions in the processing and modulation of a variety of physiological and pathological responses to external signals.
摘要
蛋白激酶C现在被认为是一个庞大的蛋白质家族，具有多个具有细微个体酶学特征的亚类。该家族的一些成员表现出不同的组织表达模式和细胞内定位；不同的激酶可能在对外部信号的各种生理和病理反应的处理和调节中具有不同的功能。
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