Bytzer P
Department of Medicine, Division of Gastroenterology, Glostrup University Hospital, DK-2600 Glostrup, Denmark.
Gut. 2004 May;53 Suppl 4(Suppl 4):iv28-34. doi: 10.1136/gut.2003.034298.
Despite major advances in our understanding of reflux disease, the management of this disorder still presents many challenges. Reduction of heartburn is the most readily apparent objective for the patient with reflux disease. Thus the ability to measure heartburn accurately is of fundamental importance to clinical research in reflux disease. Here, the available data on the assessment of reflux symptoms--predominantly heartburn--in clinical trials of symptomatic reflux disease are examined.
尽管我们对反流性疾病的认识取得了重大进展,但这种疾病的管理仍然面临许多挑战。减轻烧心症状是反流性疾病患者最明显的目标。因此,准确测量烧心症状的能力对于反流性疾病的临床研究至关重要。在此,我们将审视在有症状反流性疾病的临床试验中,有关反流症状(主要是烧心)评估的现有数据。