Lund Rikke, Holstein Bjørn Evald, Osler Merete
Department of Social Medicine, Institute of Public Health, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.
Int J Epidemiol. 2004 Apr;33(2):389-97. doi: 10.1093/ije/dyh065.
The aims of the present study are to analyse the association between marital status at age 24, 29, 34, and 39 years and subsequent mortality in a cohort of men born in 1953 (sensitive period); to study the impact of number of years married, number of years divorced/widowed, and number of marital break-ups on mortality (cumulative effect), and to examine whether these effects were independent of marital status at age 39 (proximity effect).
Prospective birth cohort study with follow-up of mortality from 1992 to 2002. Participants were 10891 men born within the metropolitan area of Copenhagen, Denmark. Marital status in 1992 as well as start and termination of all previous marital status events from 1968 to 1992 were retrieved from the Danish Civil Registration System.
Were hazard ratios (HR) for all-cause mortality from age 40 to 49 years.
We found a strong protective effect of being married compared with never being married or divorced/widowed at every age. The association increased in strength with increasing age. Number of years divorced was associated with increased mortality risk in a dose-dependent manner at age 34 and 39 years. One or more marital break-ups was associated with higher mortality, whereas increasing number of years married was associated with lower mortality. Inclusion of current marital status attenuated the strength of the associations but most of them remained statistically significant.
Marital status and cumulated marital periods, especially cumulated periods divorced/widowed are strong independent predictors of mortality among younger males.
本研究的目的是分析1953年出生队列(敏感时期)中24岁、29岁、34岁和39岁时的婚姻状况与随后死亡率之间的关联;研究结婚年限、离婚/丧偶年限以及婚姻破裂次数对死亡率的影响(累积效应),并检验这些效应是否独立于39岁时的婚姻状况(临近效应)。
前瞻性出生队列研究,对1992年至2002年的死亡率进行随访。参与者为丹麦哥本哈根大都市地区出生的10891名男性。1992年的婚姻状况以及1968年至1992年所有先前婚姻状况事件的开始和结束情况均从丹麦民事登记系统中获取。
40岁至49岁全因死亡率的风险比(HR)。
我们发现,在每个年龄段,已婚与从未结婚或离婚/丧偶相比,具有很强的保护作用。这种关联强度随着年龄的增长而增加。在34岁和39岁时,离婚年限与死亡风险增加呈剂量依赖性相关。一次或多次婚姻破裂与较高的死亡率相关,而结婚年限增加与较低的死亡率相关。纳入当前婚姻状况减弱了关联强度,但其中大多数仍具有统计学意义。
婚姻状况和累积婚姻期,尤其是累积离婚/丧偶期,是年轻男性死亡率的强有力独立预测因素。