Mössner Rotraut, Kaiser Rolf, Matern Philipp, Krüger Ullrich, Westphal Götz A, Brockmöller Jürgen, Ziegler Andreas, Neumann Christine, König Inke R, Reich Kristian
Department of Dermatology, Georg-August-University, Von-Siebold-Strasse 3, 37075 Goettingen, Germany.
Arch Dermatol Res. 2004 Jun;296(1):1-5. doi: 10.1007/s00403-004-0463-6. Epub 2004 Apr 9.
The three peroxisome proliferator-activated receptor (PPAR) subtypes alpha, delta (beta), and gamma belong to the group of nuclear receptors that act as ligand-activated transcription factors. Recently, expression of PPAR alpha and gamma in keratinocytes has been demonstrated, and ligands of PPAR alpha and gamma have been found to enhance epidermal maturation and protect against cutaneous inflammation. There is evidence for a possible role of PPARs in psoriasis, as the expression of PPAR alpha and gamma is decreased in lesional skin and treatment with PPAR gamma agonists improves psoriatic keratinocyte pathology in vitro and in vivo. We performed a case-control study to search for possible associations between variations in the genes encoding PPAR alpha and gamma and psoriasis. Seven variations in these genes were analyzed in 192 patients with chronic plaque-type psoriasis and 330 healthy controls by PCR-based methods. No association between any of the investigated PPAR variants and psoriasis was found. Our findings argue against a significant contribution of the investigated PPAR variations to the genetic basis of psoriasis.
三种过氧化物酶体增殖物激活受体（PPAR）亚型，即α、δ（β）和γ，属于作为配体激活转录因子的核受体组。最近，已证实角质形成细胞中PPARα和γ的表达，并且发现PPARα和γ的配体可促进表皮成熟并预防皮肤炎症。有证据表明PPARs在银屑病中可能起作用，因为PPARα和γ在皮损皮肤中的表达降低，并且用PPARγ激动剂治疗可在体外和体内改善银屑病角质形成细胞病理。我们进行了一项病例对照研究，以寻找编码PPARα和γ的基因变异与银屑病之间的可能关联。通过基于PCR的方法，在192例慢性斑块型银屑病患者和330例健康对照中分析了这些基因的7种变异。未发现任何研究的PPAR变体与银屑病之间存在关联。我们的研究结果表明，所研究的PPAR变异对银屑病的遗传基础没有显著贡献。
