Manina A A, Kucherenko R P, Mel'nikova L I, Strelkov R B
Arkh Anat Gistol Embriol. 1978 Jul;75(7):39-46.
Compensatory-adaptive reaction of the brain to hypoxia depends on destructive and reparative processes developing in neuronal and glial elements. A drastic tension and reconstruction of the energy apparatus--mitochondria occurs, as well as reversible disturbances in informative connections between the nucleus and cytoplasm and between nerve fibers and synapses. As a result, structural-functional activity of organells decreases along with changes in metabolic processes. Destructive processes in oligodendroglia, at all stages of the experiment, are more pronounced than in neurons. Preliminary injection of hydroxybutyric acid to the animals preserves the cellular energy potential under hypoxia, that is evident from the lack of severe alterations in mitochondria and other organells. Mechanisms of the adaptive-compensatory reaction in cortical neurons under hypoxia are connected with tension and reconstruction of all organells of the brain cellular elements and with biochemical shifts of lactate dehydrogenase enzymes.
大脑对缺氧的代偿性适应反应取决于神经元和神经胶质细胞中发生的破坏和修复过程。能量装置——线粒体出现剧烈的紧张和重构，同时细胞核与细胞质之间以及神经纤维与突触之间的信息连接出现可逆性紊乱。结果，细胞器的结构功能活性随着代谢过程的变化而降低。在实验的各个阶段，少突胶质细胞中的破坏过程比神经元中的更明显。预先给动物注射羟基丁酸可在缺氧状态下维持细胞能量潜能，这从线粒体和其他细胞器缺乏严重改变中可以明显看出。缺氧状态下皮质神经元的适应性代偿反应机制与大脑细胞成分所有细胞器的紧张和重构以及乳酸脱氢酶的生化变化有关。
