Santagostino G, Messeri E, Pezzati S, Gambi D
U.O. Anestesia e Rianimazione, USL n. 10/C, Nuovo Ospedale S. Giovanni di Dio, Firenze.
Minerva Anestesiol. 1992 Jul-Aug;58(7-8):433-6.
The effect of preheated (37 degrees C) mixture of 0.5% bupivacaine and fentanyl on peridural anaesthesia have been studied in a double blind randomized clinical trial. Fifty patients of both sexes, ASA I-II, undergoing elective surgery for inguinal hernia repair or radical saphenectomy have been randomly assigned either to the control group (n = 25) receiving 0.5% bupivacaine-fentanyl at room temperature (20 degrees C), or to the group receiving the same anaesthetic mixture preheated for 12 hours up to 37 degrees C (n = 25). The latency period, extension, duration and quality of anaesthetic block were evaluated. A significative difference in the extension of anaesthetic block was detected at 6' (p less than 0.05 for extension up to T10 and T11, p less than 0.025 up to T12), and at 8' (less than 0.05 for extension up to T10). However no difference was observed between the two groups at 10' and later. The use of 0.5% bupivacaine-fentanyl mixture resulted in a short latency period, as previously observed, and its preheating does not seem to affect substantially the parameters evaluated in this study.
在一项双盲随机临床试验中，研究了预热至37摄氏度的0.5%布比卡因和芬太尼混合物对硬膜外麻醉的效果。50例ASA I-II级、接受腹股沟疝修补术或大隐静脉剥脱术择期手术的男女患者，被随机分为对照组（n = 25），接受室温（20摄氏度）下的0.5%布比卡因-芬太尼，或接受预热12小时至37摄氏度的相同麻醉混合物的组（n = 25）。评估了麻醉阻滞的潜伏期、范围、持续时间和质量。在6分钟时，麻醉阻滞范围有显著差异（T10和T11水平的范围p < 0.05，T12水平p < 0.025），在8分钟时（T10水平的范围< 0.05）。然而，在10分钟及以后两组之间未观察到差异。如先前观察到的，使用0.5%布比卡因-芬太尼混合物导致潜伏期较短，并且其预热似乎并未对本研究中评估的参数产生实质性影响。
