Diallo B, Nolte H
Reg Anaesth. 1984 Apr;7(2):33-8.
A double blind clinical trial was carried out on randomised groups of 20 patients each undergoing surgery for varicose veins to compare the actions of etidocaine 1% and bupivacaine 0.5% and 0.75% with adrenaline 1:200.000. Bupivacaine 0.75% and etidocaine 1% were found to be equipotent, with a rapid onset and long duration of anaesthesia, and a comparable degree of profound motor block. The latency period of Etidocaine was markedly increased in the L V and S I segments, probably due to its high fat solubility. 0.5% bupivacaine, compared to the other preparations, showed significantly less motor block and duration of analgesia. Unlike other investigators, "spotty-analgesia" was not found in this series.
对每组20例接受静脉曲张手术的患者进行随机分组的双盲临床试验，以比较1%依替卡因、0.5%和0.75%布比卡因与1:200,000肾上腺素的作用。发现0.75%布比卡因和1%依替卡因等效，起效迅速，麻醉持续时间长，且深度运动阻滞程度相当。依替卡因在腰4、5和骶1节段的潜伏期明显延长，可能是由于其高脂溶性。与其他制剂相比，0.5%布比卡因的运动阻滞和镇痛持续时间明显较短。与其他研究者不同，本系列未发现“点状镇痛”。
