Tohgi H, Abe T, Takahashi S, Kimura M, Takahashi J, Kikuchi T
Department of Neurology, Iwate Medical University, Morioka, Japan.
Neurosci Lett. 1992 Jul 6;141(1):9-12. doi: 10.1016/0304-3940(92)90322-x.
We studied concentrations of free and total serotonin (5-hydroxytryptamine, 5-HT) and its related substances in the cerebrospinal fluid from patients with Alzheimer type dementia (ATD) compared with controls. In ATD patients, concentrations of total 5-HT, tryptophan, 5-hydroxytryptophan (5-HTP), melatonin, kynurenine, and 3-hydroxykynurenine decreased significantly. The rate of concentration of tryptophan metabolites to that of tryptophan was significantly reduced for total 5-HT and 3-hydroxykynurenine only. The 5-hydroxyindoleacetic acid (5-HIAA)/5-HT ratio was significantly larger in ATD patients than in controls. The greater reduction in the 3-hydroxykynurenine concentration (81% vs. controls) than in the total 5-HT concentration (51% vs. controls) suggests that the metabolism of tryptophan to 5-HT and 3-hydroxykynurenine is in favor of 5-HT.
我们研究了阿尔茨海默型痴呆（ATD）患者脑脊液中游离和总血清素（5-羟色胺，5-HT）及其相关物质的浓度，并与对照组进行比较。在ATD患者中，总5-HT、色氨酸、5-羟色氨酸（5-HTP）、褪黑素、犬尿氨酸和3-羟基犬尿氨酸的浓度显著降低。仅总5-HT和3-羟基犬尿氨酸的色氨酸代谢物浓度与色氨酸浓度的比率显著降低。ATD患者的5-羟吲哚乙酸（5-HIAA）/5-HT比值显著高于对照组。3-羟基犬尿氨酸浓度的降低幅度（81%，相对于对照组）大于总5-HT浓度的降低幅度（51%，相对于对照组），这表明色氨酸向5-HT和3-羟基犬尿氨酸的代谢更倾向于生成5-HT。
