Tohgi H, Abe T, Takahashi S, Kimura M
Department of Neurology, Iwate Medical University, Morioka, Japan.
Neurosci Lett. 1992 Jul 6;141(1):5-8. doi: 10.1016/0304-3940(92)90321-w.
We determined the concentrations of the putative transmitter amino acids in the cerebrospinal fluid of patients with Alzheimer type dementia (ATD) and vascular dementia of the Binswanger type (VDBT). In ATD, aspartate and glutamate concentrations were significantly and selectively reduced, while in VDBT, concentrations of aspartate, glutamate, gamma-aminobutyric acid (GABA) and many other amino acids were decreased non-selectively. In both ATD and VDBT, we found a tendency for all amino acids to increase with progression of the disease, and this reached statistical significance for some amino acids.
我们测定了阿尔茨海默型痴呆（ATD）患者和宾斯旺格型血管性痴呆（VDBT）患者脑脊液中假定递质氨基酸的浓度。在ATD中，天冬氨酸和谷氨酸浓度显著且选择性降低，而在VDBT中，天冬氨酸、谷氨酸、γ-氨基丁酸（GABA）和许多其他氨基酸的浓度非选择性降低。在ATD和VDBT中，我们发现所有氨基酸浓度都有随疾病进展而升高的趋势，并且某些氨基酸的这种趋势达到了统计学显著性。
