Ferroni C, Selis L, Mutti A, Folli D, Bergamaschi E, Franchini I
Laboratory of Industrial Toxicology, University of Parma, Italy.
Neurotoxicology. 1992 Spring;13(1):243-7.
The hypothesis that long-term low-level exposure to perchloroethylene (PERC) may impair the dopaminergic control of prolactin (PRL) secretion and negatively affect neurobehavioral performance, was tested in a cross-sectional survey of dry-cleaners. Sixty female workers exposed to PERC in dry-cleaning shops and thirty controls recruited in a cleaning plant not using solvents were examined. PERC air concentration during four-hour random periods varied from 1 to 67 ppm (median 15 ppm). PERC blood levels ranged 12-864 mg/l (median 145 mg/l). A set of tests from a computer-based performance evaluation system was administered, including Finger Tapping with both dominant and non-dominant hands, Simple Reaction Times, Digit Symbol, and Shape Comparison in two different versions constructed to test Vigilance and the response to moderate stress, respectively. During the proliferative phase of the menstrual cycle, PERC-exposed workers showed increased serum PRL (12.1 +/- 6.7 ng/ml) as compared to their matched controls (7.4 +/- 3.1 ng/ml, p less than 0.001). Prolonged reaction times were also observed in all tests. However, neither the duration of exposure nor air and blood PERC concentrations were significantly correlated with performance. Nor were exposure variables associated with the increased PRL levels.
在一项针对干洗店员工的横断面调查中，对长期低水平接触全氯乙烯（PERC）可能损害多巴胺能对催乳素（PRL）分泌的控制并对神经行为表现产生负面影响这一假设进行了检验。研究人员检查了60名在干洗店接触PERC的女性工人以及30名在不使用溶剂的清洁厂招募的对照人员。在随机的4小时时间段内，PERC空气浓度在1至67 ppm之间变化（中位数为15 ppm）。PERC血液水平在12 - 864 mg/l之间（中位数为145 mg/l）。研究人员实施了一套基于计算机的性能评估系统测试，包括用优势手和非优势手进行手指敲击、简单反应时间、数字符号以及两种不同版本的形状比较，这两种版本分别用于测试警觉性和对中度压力的反应。在月经周期的增殖期，与匹配的对照人员相比，接触PERC的工人血清PRL升高（12.1±6.7 ng/ml），而对照人员为（7.4±3.1 ng/ml，p<0.001）。在所有测试中还观察到反应时间延长。然而，接触持续时间、空气和血液中的PERC浓度均与性能无显著相关性。接触变量也与PRL水平升高无关。
