Altmann L, Neuhann H F, Krämer U, Witten J, Jermann E
Department of Neurotoxicology, Heinrich-Heine-University Düsseldorf, Federal Republic of Germany.
Environ Res. 1995 May;69(2):83-9. doi: 10.1006/enrs.1995.1028.
The effects of chronic low-level tetrachloroethene (TCE) exposure on functions of the central nervous system (CNS) were measured in subjects living in the neighborhood of dry cleaning shops with a mean residential time of 10.6 years. Neurobehavioral tests were performed using a German version of the NES battery. Additionally, a pattern reversal visual-evoked potentials (VEPs) were recorded. the mean blood TCE concentration in the subjects was 17.8 micrograms/liter and the median indoor TCE air concentration measured in the residences was 1.36 mg/m3. The outcome of the NES subtests for vigilance, simple reaction time, as well as visual memory differed statistically significantly between the exposed subjects and the controls, whereas for VEP latencies the differences were statistically not significant. It is concluded that despite the low exposure levels, CNS functions might be affected by TCE in subjects living close to a dry cleaning facility if the exposure lasts for several years.
在居住于干洗店附近、平均居住时间为10.6年的人群中，测量了长期低水平四氯乙烯（TCE）暴露对中枢神经系统（CNS）功能的影响。使用德语版NES测试组合进行神经行为测试。此外，记录了模式翻转视觉诱发电位（VEP）。受试者的平均血液TCE浓度为17.8微克/升，所测住宅室内TCE空气浓度中位数为1.36毫克/立方米。暴露组受试者与对照组在NES测试中关于警觉性、简单反应时间以及视觉记忆的子测试结果存在显著统计学差异，而VEP潜伏期差异无统计学意义。得出的结论是，尽管暴露水平较低，但对于居住在干洗设施附近的人群，如果暴露持续数年，CNS功能可能会受到TCE的影响。
