Schwartz Erich J, Longacre Teri A
Department of Pathology, Stanford University, Stanford, California 94305, USA.
Int J Gynecol Pathol. 2004 Apr;23(2):123-8. doi: 10.1097/00004347-200404000-00006.
Adenomatoid tumors are benign proliferations most often encountered in the female and male genital tracts. The mesothelial phenotype of these unusual tumors has been established by a variety of ultrastructural and immunohistochemical studies, although their etiology is by no means certain. The expression of the Wilms' tumor suppressor gene, WT1, in normal, hyperplastic, and malignant mesothelial cells prompted us to analyze the expression pattern of WT1 in a series of 24 adenomatoid tumors occurring in the uterus, fallopian tube, ovary, epididymis, scrotum, and testis. Twenty-three of the tumors expressed WT1 protein and the same number expressed calretinin, another marker of mesothelial differentiation. The one tumor that failed to stain with calretinin was positive for WT1. These results provide further support for mesothelial differentiation of adenomatoid tumors and suggest that the presence of WT1 expression may be useful in the differential diagnosis of these uncommon neoplasms, especially when they present in unusual settings or expression of other mesothelial markers is absent.
腺瘤样瘤是一种良性增殖性病变，最常见于女性和男性生殖道。尽管其病因尚不确定，但通过各种超微结构和免疫组织化学研究已证实这些不寻常肿瘤具有间皮细胞表型。Wilms肿瘤抑制基因WT1在正常、增生和恶性间皮细胞中的表达促使我们分析WT1在一系列发生于子宫、输卵管、卵巢、附睾、阴囊和睾丸的24例腺瘤样瘤中的表达模式。其中23例肿瘤表达WT1蛋白，同样数量的肿瘤表达钙视网膜蛋白，这是间皮分化的另一个标志物。唯一一例未被钙视网膜蛋白染色的肿瘤WT1呈阳性。这些结果进一步支持了腺瘤样瘤的间皮分化，并表明WT1表达的存在可能有助于这些罕见肿瘤的鉴别诊断，特别是当它们出现在不寻常的情况下或其他间皮标志物缺乏表达时。
