Hu Zhi-Xiong, Tan Min-Hua, Li Qiong-Zhen, Xu Jia-Li, Chen Wei, Xie Zhi-Hao, Zhou Yong-Jian, Liang Qing, An Jian-Hong, Shen Hong
Department of Pathology, The First People's Hospital of Zhaoqing, Zhaoqing 526020, Guangdong Province, China.
Department of Gynaecology and Obstetrics, The First People's Hospital of Zhaoqing, Zhaoqing 526020, Guangdong Province, China.
World J Clin Oncol. 2020 Dec 24;11(12):1076-1083. doi: 10.5306/wjco.v11.i12.1076.
To investigate the clinicopathological features of endometrial clear cell carcinoma that has invaded the right oviduct with a cooccurring ipsilateral oviduct adenomatoid tumor.
A case of endometrial clear cell carcinoma invading the right oviduct with a cooccurring ipsilateral oviduct adenomatoid tumor was collected and analyzed using pathomorphology and immunohistochemistry. Endometrial clear cell carcinoma cells were distributed in a solid nest, papillary, shoe nail-like, and glandular tube-like distribution. There was infiltrative growth, and tumor cells had clear cytoplasm and obvious nuclear heteromorphism. The cancer tissue was necrotic and mitotic. The cancer tissue invaded the right oviduct. The ipsilateral oviduct also had an adenomatoid tumor. The adenomatoid tumor was arranged in microcapsules lined with flat or cubic cells that were surrounded by smooth muscle tissue. The adenomatoid tumor cells were round in shape.
Clear cell carcinoma of the endometrium can invade the oviduct and occur simultaneously with tubal adenomatoid tumors. Upon pathological diagnosis, one should pay close attention to distinguishing whether an endometrial clear cell carcinoma is invading the oviduct or whether it is accompanied by an adenomatoid tumor of the oviduct. Immunohistochemistry is helpful to differentiate these two disease entities. Endometrial clear cell carcinomas express Napsin-A and P16 and are negative for estrogen receptor and progesterone receptor. The presence of endometrial clear cell carcinoma does not affect the expression of CK and calretinin in adenomatoid tumors.
探讨侵犯右侧输卵管并同时伴有同侧输卵管腺瘤样瘤的子宫内膜透明细胞癌的临床病理特征。
收集1例侵犯右侧输卵管并同时伴有同侧输卵管腺瘤样瘤的子宫内膜透明细胞癌病例，采用病理形态学及免疫组织化学方法进行分析。子宫内膜透明细胞癌细胞呈实性巢状、乳头状、鞋钉样及腺管状分布。呈浸润性生长，肿瘤细胞胞质透明，核异型性明显。癌组织有坏死及核分裂象。癌组织侵犯右侧输卵管。同侧输卵管还存在腺瘤样瘤。腺瘤样瘤呈微囊状排列，内衬扁平或立方细胞，周围有平滑肌组织。腺瘤样瘤细胞呈圆形。
子宫内膜透明细胞癌可侵犯输卵管并与输卵管腺瘤样瘤同时发生。病理诊断时应注意鉴别是子宫内膜透明细胞癌侵犯输卵管还是伴有输卵管腺瘤样瘤。免疫组织化学有助于鉴别这两种疾病实体。子宫内膜透明细胞癌表达Napsin-A和P16，雌激素受体和孕激素受体阴性。子宫内膜透明细胞癌的存在不影响腺瘤样瘤中CK和钙视网膜蛋白的表达。
