Saxena Romil, Theise Neil
Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Semin Liver Dis. 2004 Feb;24(1):43-8. doi: 10.1055/s-2004-823100.
The canals of Hering (CoH) begin in the lobules, are lined partially by cholangiocytes and partly by hepatocytes, and conduct bile from bile canaliculi to terminal bile ducts in portal tracts. They are not readily apparent on routine histological staining but are highlighted by the biliary cytokeratins CK19 and CK7. There is on average 1 CoH per 10 microm of bile duct length. The canals represent the true hepatocytic-biliary interface that thus lies within the lobule and not at the limiting plate. The CoH are destroyed early in primary biliary cirrhosis, perhaps explaining lobular "hepatitis" in this disease. They may also be the primary sites of scarring in methotrexate toxicity. Most intriguingly, the CoH have been speculated to harbor intraorgan stem cells of the liver, perhaps forming the hepatic stem cell "niche" and have been demonstrated to proliferate in disease states.
赫林管（CoH）始于肝小叶，部分由胆管细胞衬里，部分由肝细胞衬里，将胆小管中的胆汁输送到门管区的终末胆管。它们在常规组织学染色中不易显现，但可通过胆管细胞角蛋白CK19和CK7突显出来。平均每10微米胆管长度有1条赫林管。这些管道代表真正的肝细胞 - 胆管界面，因此位于肝小叶内而非界板处。在原发性胆汁性肝硬化早期，赫林管会遭到破坏，这或许可以解释该疾病中的小叶性“肝炎”。它们也可能是甲氨蝶呤毒性瘢痕形成的主要部位。最引人注目的是，有人推测赫林管中含有肝脏的器官内干细胞，可能形成肝干细胞“龛”，并且已证实在疾病状态下会增殖。
