Ewing C Alexander, Kalan Mohammed, Chucker Francis, Ozdemirli Metin
Department of Pathology, Georgetown University Hospital, Washington, DC 20007, USA.
Arch Pathol Lab Med. 2004 May;128(5):565-7. doi: 10.5858/2004-128-565-MCIPLN.
Melanosis coli is a well-known condition in which macrophages filled with a lipofuscin-like pigment are found in the colonic lamina propria. The condition has been associated with the ingestion of anthracene laxatives and is believed to be caused by increased epithelial apoptosis. Although melanosis coli is a frequent finding in colonic biopsies and resection specimens, to our knowledge the presence of identical pigment in macrophages of pericolonic lymph nodes has been reported in only 4 other patients in the English literature. We report the case of a patient who underwent a left hemicolectomy for colonic adenocarcinoma and was found incidentally to have melanosis coli associated with long-term use of the herbal laxative Swiss Kriss, not only in his colonic mucosa, but also in the colonic submucosa and in his pericolonic lymph nodes.
结肠黑变病是一种众所周知的病症，在结肠固有层中可发现充满脂褐素样色素的巨噬细胞。该病症与蒽醌类泻药的摄入有关，据信是由上皮细胞凋亡增加所致。尽管结肠黑变病在结肠活检和切除标本中很常见，但据我们所知，英文文献中仅另有4例报道在结肠旁淋巴结的巨噬细胞中存在相同色素。我们报告了1例因结肠腺癌接受左半结肠切除术的患者，偶然发现其患有与长期使用草药泻药瑞士克莉丝相关的结肠黑变病，不仅在其结肠黏膜中存在，在结肠黏膜下层和结肠旁淋巴结中也存在。
