Byers R J, Marsh P, Parkinson D, Haboubi N Y
Department of Pathological Sciences, University of Manchester, UK.
Histopathology. 1997 Feb;30(2):160-4. doi: 10.1046/j.1365-2559.1997.d01-574.x.
We have investigated the clinical presentation, laxative use and histopathology of 38 patients with a histological diagnosis of melanosis coli and measured the colonic epithelial apoptosis in these cases. The presence of lipofuscin was confirmed in all cases. Fifteen of the cases had constipation, whilst eight had diarrhoea. Neither constipation nor diarrhoea was present in 13 cases and both were present, at different times, in two. Laxatives had been used in all those with constipation, in only one with diarrhoea and in none of the others. The mean apoptotic count was significantly increased in those with melanosis coli compared with the controls. In the majority of cases with constipation there was no other abnormality, whilst an additional diagnosis was present in the majority of the remainder. Colonic epithelial apoptosis was increased in melanosis coli and the majority of cases were not associated with laxative use. These results support the proposed role of apoptosis in melanosis coli, but indicate that melanosis coli is a non-specific marker of increased apoptosis with many possible causes, of which the use of laxatives is only one.
我们对38例经组织学诊断为结肠黑变病的患者的临床表现、泻药使用情况及组织病理学进行了研究，并测定了这些病例的结肠上皮细胞凋亡情况。所有病例均证实存在脂褐素。其中15例有便秘，8例有腹泻。13例既无便秘也无腹泻，2例在不同时间既有便秘又有腹泻。所有便秘患者均使用过泻药，仅有1例腹泻患者使用过泻药，其他患者均未使用。与对照组相比，结肠黑变病患者的平均凋亡计数显著增加。大多数便秘病例无其他异常，而其余大多数病例有额外诊断。结肠黑变病患者的结肠上皮细胞凋亡增加，大多数病例与使用泻药无关。这些结果支持了细胞凋亡在结肠黑变病中所起的作用，但表明结肠黑变病是细胞凋亡增加的非特异性标志物，其原因众多，使用泻药只是其中之一。
