Garbow Joel R, Zhang Zhongqiu, You Ming
Department of Chemistry, Washington University, St. Louis, Missouri, USA.
Cancer Res. 2004 Apr 15;64(8):2740-2. doi: 10.1158/0008-5472.can-03-3258.
This report describes recent efforts to develop and apply small animal magnetic resonance imaging methods to the study of lung tumors in mice. Magnetic resonance (MR) images obtained with respiratory gating, with data collection synchronized with the respiration of the animal, allow visualization of submillimeter tumors in animals treated with a lung carcinogen. Comparison of the MR images with gross pathology of these lungs demonstrates the utility of the imaging methods for measuring tumor burden. As a noninvasive imaging modality that uses nonionizing radiation, MR is well suited to longitudinal studies aimed at understanding the factors that control the onset and development of lung tumors and their response to therapy in a wide variety of animal models.
本报告描述了近期为开发和应用小动物磁共振成像方法以研究小鼠肺部肿瘤所做的努力。通过呼吸门控获得的磁共振（MR）图像，其数据采集与动物呼吸同步，能够在接受肺部致癌物处理的动物体内可视化亚毫米级肿瘤。将MR图像与这些肺部的大体病理学进行比较，证明了成像方法在测量肿瘤负荷方面的实用性。作为一种使用非电离辐射的非侵入性成像方式，MR非常适合进行纵向研究，旨在了解控制肺部肿瘤发生和发展的因素以及它们在各种动物模型中对治疗的反应。
