Oli J M, Watkins P J, Wild B, Adegoke O J
Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria.
Diabet Med. 2004 May;21(5):483-6. doi: 10.1111/j.1464-5491.2004.1134.x.
To determine the prevalence of albuminuria [raised albumin-creatinine ratio (ACR)] in an out-patient population of Afro-Caribbeans with Type 2 diabetes mellitus (DM) and to determine if the possession of the sickle cell trait (SCT) is a risk factor.
The ACR in a morning urine sample was determined in each of 181 Afro-Caribbeans with Type 2 DM attending the out-patient clinic at King's Diabetes Centre of King's College Hospital, London. The subjects were genotyped for the SCT, Haemoglobin AS (HbAS).
Although a raised ACR was demonstrated more frequently in those with the SCT than in those without, with an odds ratio of 1.19, this was not statistically significant (P = 0.68).
In this study the possession of the SCT does not appear to play a significant role in the development of albuminuria. However, a larger study is needed to clarify its role as a risk factor for development of albuminuria in Afro-Caribbeans with Type 2 DM.
确定患有2型糖尿病（DM）的非洲加勒比裔门诊患者中蛋白尿[升高的白蛋白-肌酐比值（ACR）]的患病率，并确定镰状细胞性状（SCT）是否为一个风险因素。
在伦敦国王学院医院国王糖尿病中心门诊就诊的181例患有2型DM的非洲加勒比裔患者中，测定了晨尿样本中的ACR。对这些受试者进行了SCT（血红蛋白AS，HbAS）基因分型。
尽管SCT患者中ACR升高的情况比无SCT患者更常见，优势比为1.19，但这在统计学上并不显著（P = 0.68）。
在本研究中，SCT似乎在蛋白尿的发生中不起重要作用。然而，需要更大规模的研究来阐明其作为患有2型DM的非洲加勒比裔患者蛋白尿发生风险因素的作用。
