Chaturvedi N, McKeigue P M, Marmot M G
Department of Epidemiology and Public Health, University College, London, UK.
Diabetologia. 1994 Aug;37(8):765-72. doi: 10.1007/BF00404333.
Afro-Caribbeans have low mortality rates from coronary heart disease, despite a high prevalence of diabetes mellitus. We examined 1166 Afro-Caribbean and European men and women aged 40-64 years in a community survey in London, UK. Prevalence of glucose intolerance (combining impaired glucose tolerance, new and known diabetes) was 31% in Afro-Caribbeans and 14% in Europeans (p < 0.001). In men, the prevalence of probable coronary heart disease was 6% in Afro-Caribbeans and 13% in Europeans (p < 0.01). Triglyceride was lower in Afro-Caribbeans than Europeans; in men, HDL cholesterol was higher. Afro-Caribbean men were less centrally obese, while Afro-Caribbean women were more centrally obese than their European counterparts. Fasting and 2-h insulin levels were higher in Afro-Caribbeans than Europeans. Glucose intolerance was associated with high triglyceride, low HDL cholesterol and central obesity in European but not in Afro-Caribbean men. In Europeans, fasting triglyceride was 1.49 mmol/l in normoglycaemic and 1.89 mmol/l in glucose intolerant men (p < 0.05), in Afro-Caribbean men triglyceride was 1.08 and 1.22 mmol/l, respectively. Waist hip ratio was 0.94 in normoglycaemic, and 0.98 in glucose intolerant European men (p < 0.001). In Afro-Caribbean men, waist hip ratio was 0.93 in both groups. At each level of insulin, glucose or central obesity, triglyceride was lower in Afro-Caribbean men and women than in Europeans. We speculate that despite high insulin levels, Afro-Caribbeans have a favourable lipoprotein pattern which persists in the presence of glucose intolerance, and may be related to body fat distribution.(ABSTRACT TRUNCATED AT 250 WORDS)
尽管糖尿病患病率很高，但非洲裔加勒比人冠心病死亡率较低。我们在英国伦敦的一项社区调查中，对1166名年龄在40 - 64岁的非洲裔加勒比人和欧洲男性及女性进行了研究。非洲裔加勒比人糖耐量异常（包括糖耐量受损、新诊断和已知糖尿病）的患病率为31%，欧洲人为14%（p < 0.001）。在男性中，非洲裔加勒比人可能患冠心病的患病率为6%，欧洲人为13%（p < 0.01）。非洲裔加勒比人的甘油三酯水平低于欧洲人；在男性中，高密度脂蛋白胆固醇水平更高。非洲裔加勒比男性腹部肥胖程度较低，而非洲裔加勒比女性比欧洲女性腹部肥胖程度更高。非洲裔加勒比人的空腹和2小时胰岛素水平高于欧洲人。糖耐量异常与欧洲男性的高甘油三酯、低高密度脂蛋白胆固醇和腹部肥胖有关，但在非洲裔加勒比男性中并非如此。在欧洲人中，血糖正常男性的空腹甘油三酯为1.49 mmol/l，糖耐量异常男性为1.89 mmol/l（p < 0.05），在非洲裔加勒比男性中，甘油三酯分别为1.08和1.22 mmol/l。血糖正常的欧洲男性腰臀比为0.94，糖耐量异常的为0.98（p < 0.001）。在非洲裔加勒比男性中，两组的腰臀比均为0.93。在胰岛素、血糖或腹部肥胖的每个水平上，非洲裔加勒比男性和女性的甘油三酯水平都低于欧洲人。我们推测，尽管胰岛素水平较高，但非洲裔加勒比人有良好的脂蛋白模式，在糖耐量异常情况下依然存在，这可能与身体脂肪分布有关。（摘要截选至250词）
