Liechty Cheryl A, Alexander Christopher S, Harrigan P Richard, Guzman J David, Charlebois Edwin D, Moss Andrew R, Bangsberg David R
Division of Infectious Diseases, University of California San Francisco, San Francisco, CA, USA.
AIDS. 2004 Jan 2;18(1):127-9. doi: 10.1097/00002030-200401020-00017.
We examined cross-sectionally the relationship between untimed drug levels and adherence in 83 individuals. Abnormally low untimed antiretroviral drug levels were sensitive in identifying individuals adherent to 60% or less of medication doses over 3 - 5-week period. An abnormally low drug level was associated with a higher viral load. A single abnormally low untimed antiretroviral drug level can identify an individual with very low adherence at high risk of HIV disease progression and death.
我们对83名个体进行了横断面研究，以考察非定时药物水平与依从性之间的关系。在3至5周的时间内，非定时抗逆转录病毒药物水平异常低对于识别服药剂量依从性在60%及以下的个体很敏感。药物水平异常低与较高的病毒载量相关。单次非定时抗逆转录病毒药物水平异常低能够识别出依从性极低且处于HIV疾病进展和死亡高风险的个体。
