Imazu K, Fujishiro K, Inoue N, Koga M, Iwasa T
Third Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
J UOEH. 1992 Mar 1;14(1):73-6. doi: 10.7888/juoeh.14.73.
We investigated the toxicity of dichloropropanols (DCPs) in hematological findings and serum chemistry. The solutions of two isomers of DCPs, 1,3-dichloro-2-propanol (DC2P) and 2,3-dichloro-1-propanol (DC1P) were dissolved in saline at the concentration of 100 mg/ml, and 0.1 ml of each solution was subcutaneously injected into male Wistar rats weighing about 200 g. At 6 hours after the injections, in the DC2P group, the number of white blood cells and platelets showed a significant decrease. Transaminases, alkaline phosphatase and lactate dehydrogenase were greatly elevated. Blood urea nitrogen and creatinine also showed a significant increase. There were no changes in the measurements in the DC1P group. These results indicate that there is a prominent hepatotoxicity in DC2P, and that there is a considerable difference in the toxicity present in DC2P and DC1P. Furthermore, in the workplace where DCPs, especially DC2P, is used, the monitoring of the working environment and biological monitoring should be mandatory.
我们研究了二氯丙醇（DCPs）对血液学指标和血清生化指标的毒性。将DCPs的两种异构体1,3-二氯-2-丙醇（DC2P）和2,3-二氯-1-丙醇（DC1P）的溶液以100mg/ml的浓度溶解于生理盐水中，将每种溶液0.1ml皮下注射到体重约200g的雄性Wistar大鼠体内。注射后6小时，在DC2P组中，白细胞和血小板数量显著减少。转氨酶、碱性磷酸酶和乳酸脱氢酶大幅升高。血尿素氮和肌酐也显著增加。DC1P组的测量值没有变化。这些结果表明DC2P具有显著的肝毒性，并且DC2P和DC1P的毒性存在相当大的差异。此外，在使用DCPs尤其是DC2P的工作场所，必须对工作环境进行监测和进行生物监测。
